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Allele : Stat3<em1Mcoo> signal transducer and activator of transcription 3; endonuclease-mediated mutation 1, Megan A Cooper

Primary Identifier  MGI:7398577 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Stat3
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  Using CRISPR/CAS9 technology, a single nucleotide change was introduced into the Stat3 gene to create a knock-in mouse model harboring a de novo pathogenic human STAT3 variant (p.G421R).
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • STAT3 GOF,
  • Stat3<p.G421R>,
  • STAT3 GOF,
  • Stat3<p.G421R>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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2 Publication categories

Trail: Allele