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Allele : Tg(tetO/Prnp-SNCA*A53T)4360Tmd transgene insertion 4360, Ted M Dawson
Primary Identifier  MGI:7428915 Allele Type  Transgenic
Attribute String  Humanized sequence, Inducible, Inserted expressed sequence Gene  Tg(tetO/Prnp-SNCA*A53T)4360Tmd
Strain of Origin  (C57BL/6 x C3H)F2 Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  The transgenic construct contains the tet promoter (tetO) and mouse prion protein non-coding exons 1-2 upstream of the human SNCA cDNA containing the A53T mutation, followed by mouse prion protein non-coding exon 3. Three lines with high copy number were generated (hA53T-4360, hA53T-4299, hA53T-4454). This is the highest expressing line.
  • mutations:
  • Insertion
  • synonyms:
  • TetP-hA53T alpha-syn,
  • TetP-hA53T alpha-syn
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Driven By

3 Publication categories

Trail: Allele




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