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Allele : Zbp1<em3Mpa> Z-DNA binding protein 1; endonuclease-mediated mutation 3, Manolis Pasparakis

Primary Identifier	MGI:7408307	Allele Type	Endonuclease-mediated
Attribute String	Not Specified	Gene	Zbp1
Strain of Origin	C57BL/6N	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR-targeting introduced the mutation responsible for the amino acid substitutions asparagine with aspartic acid at positions 46 and 122 (N46D, N122D) and tyrosine with alanine at positions 50 and 126 (Y50A, Y126A).

mutations:
Nucleotide substitutions

synonyms:
Zbp1<mZalpha1-2>,
Zbp1<mZalpha>,
Zbp1<mZalpha1-2>,
Zbp1<mZalpha>

earliestPublication:
Jiao H, et al. (2020) Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature 580(7803):391-395

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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