| Primary Identifier | MGI:7411367 | Allele Type | Transposon induced |
| Attribute String | Conditional ready, Modified regulatory region, Null/knockout, Reporter | Gene | Del(15Rr334-Cyrib)14Fsp |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Cre-mediated inter-chromosomal recombination between Tn(sb-SBlac)15.194575Fsp at chr15:63175856-63175857 (GRCm39) and Tn(sb-SBlac)15.192331Fsp at chr15:63871640-63871641 deleted approximately 696 kb and leaves one intact copy of the transposon cassette (in reverse orientation) at the deletion junction. The transposon consists of a Sleeping Beauty transposon inverted repeat, loxP site, human beta-globin HBB minimal promoter, the lacZ beta-galactosidase reporter gene, SV40 poly(A) signal sequence, and a Sleeping Beauty transposon direct repeat. This deletion is the complement of duplication Dp(15Rr334-Cyrib)1Fsp. The centromeric part of the deleted sequence is part of the Myc topologically associating domain (TAD) and the deletion deletes Myc enhancers Rr334, Rr316124, Rr313933, Rr331, Rr307328, Rr332, Rr307330, Rr333, Rr313939 and Rr313944, the Gsdmc gene cluster, and the 3' end of Cyrib. |
