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Allele : Thtpa<em1(IMPC)Tcp> thiamine triphosphatase; endonuclease-mediated mutation 1, The Centre for Phenogenomics

Primary Identifier  MGI:7435548 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Thtpa
Inheritance Mode  Not Specified Strain of Origin  C57BL/6NCrl
Is Recombinase  false Is Wild Type  false
Project Collection  IMPC
molecularNote  This allele was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with single guide RNAs having spacer sequences of AGCACCAAACAGCGGUACCU targeting the 5' side and GAAUCAAUGGCAUCGACCAA targeting the 3' side of a critical region (ENSMUSG00000045691.15). This resulted in a 2695-bp deletion chr14:55332584 to 55335278 (GRCm39) which deleted the entire open reading frame.
  • mutations:
  • Intragenic deletion
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

3 Publication categories