| Primary Identifier | MGI:7438176 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Adgrg6 |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology generated an exon 7 deletion that is predicted to cause a translational frame-shift and generate a premature termination codon in exon 8, thus preventing translation of all isoforms. Transcript levels are abrogated in homozygotes indicating a null allele. ISH confirmed the absence of endocardial expression in E11.5 homozygous mutant hearts. |
