| Primary Identifier | MGI:7446725 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(Alb-cre/ERT2)#Nor |
| Strain of Origin | Not Specified | Induced With | tamoxifen |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | A cre/ERT2 fusion protein was inserted into a BAC clone (RP23-279P6) containing 200kb sequences including the transcriptional regulatory elements of the Alb (albumin) and Afp (a-fetoprotein) genes in their original chromosomal arrangement. Recombination inserted the CreERT2 cassette within Alb exon1, thereby disrupting Alb coding sequences on the BAC but preserving the promoter and relevant 5ÂŽ regulatory elements. The expression is restricted to the liver only with tamoxifen-inducible activation. |
