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Allele : Dis3<em1Dean> DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; endonuclease-mediated mutation 1, Jurien Dean

Primary Identifier	MGI:7447487	Allele Type	Endonuclease-mediated
Attribute String	Conditional ready	Gene	Dis3
Strain of Origin	(C57BL/6 x DBA/2)F2	Is Recombinase	false
Is Wild Type	false

molecularNote

The targeting construct is designed using CRISPR/cas9 genome editing to insert a loxP site upstream of exon 3 and a loxP site downstream of exon 5.

mutations:
Insertion

synonyms:
Dis3-flox,
Dis3<em1Jdean>,
Dis3-flox,
Dis3<em1Jdean>

earliestPublication:
Wu D, et al. (2023) Reduced female fertility due to sequestration of RNA Pol II by pervasive transcription in exosome RNase-depleted oocytes. Cell Rep 42(10):113247

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

4 Publication categories

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