| Primary Identifier | MGI:7464883 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Null/knockout | Gene | Dnm2 |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Serine codon 619 (TCG) in exon 16 was changed to leucine (CTG) (p.S619L NM_001039520.2:c.1855_1856delTCinsCT) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 15. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation is found in some autosomal dominant centronuclear myopathy (ADCNM) patients. |
