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Allele : C4b<em1Peng> complement C4B (Chido blood group); endonuclease-mediated mutation 1, Bo Peng

Primary Identifier	MGI:7450929	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	C4b
Strain of Origin	C57BL/6	Is Recombinase	false
Is Wild Type	false

molecularNote

Using CRISPR/Cas9-mediated genome editing, exons 1 and 2 of the C4b gene were targeted to generate C4b indel mutants with >83% frameshift indels.

mutations:
Intragenic deletion

synonyms:
C4b<->,
C4b<->

earliestPublication:
Zhou T, et al. (2022) Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice. Nat Commun 13(1):6233

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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