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Allele : Rr401<em1Yushi> regulatory region 401; endonuclease-mediated mutation 1, Yuichi Shima

Primary Identifier	MGI:7448545	Allele Type	Endonuclease-mediated
Attribute String	Modified regulatory region	Gene	Rr401
Is Recombinase	false	Is Wild Type	false

molecularNote

The pituitary gonadotrope-specific Nr5a1 enhancer in intron 6 was targeted with tracrRNAs and crRNAs using CRISPR/Cas9 technology, resulting in its deletion.

mutations:
Intragenic deletion

synonyms:
PE<->,
PE<->

earliestPublication:
Shima Y, et al. (2022) Intronic Enhancer Is Essential for Nr5a1 Expression in the Pituitary Gonadotrope and for Postnatal Development of Male Reproductive Organs in a Mouse Model. Int J Mol Sci 24(1)

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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