| Primary Identifier | MGI:7465211 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Vps35 |
| Inheritance Mode | Dominant | Transmission | Germline |
| Strain of Origin | 129S/SvEv | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Aspartic acid codon 620 (GAT) in exon 15 was changed to asparagine (AAT) (p.D620N) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 15. The neo cassette was removed through subsequent Cre-mediated recombination. The equivalent human mutation is found in some familial type 17 Parkinsonâs disease (PARK17) patients. |
