| Primary Identifier | MGI:7466923 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Ctnna1 |
| Inheritance Mode | Dominant | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Phenylalanine codon 72 (TTC) in exon 3 was changed to serine (TCC) (p.F72S) using an sgRNA (targeting AAGCAACTGAGAATTTCTTGG) and an ssODN template (CCATGTTTTGGCTGCATCTGTTGAACAAGCAACTGAGAATTCCTTGGAAAAGGGGGATAAAATTGCAAAAGAGAGCCAGT) with CRIPSR/Cas9 technology. The equivalent human mutation is found in some familial exudative vitreoretinopathy (FEVR) patients. |
