| Primary Identifier | MGI:7482230 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(CAG-cre/ERT2/Hif1a)#Heh |
| Strain of Origin | Not Specified | Induced With | tamoxifen and hypoxia |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | The transgene containing the CAG promoter that drives ubiquitous expression of the tamoxifen-inducible cre recombinase gene (cre/ERT2) fused with the oxygen-dependent degradation (ODD) domain of Hif1a. This transgene is responsive to hypoxia. Under normoxic conditions, the ODD is hydroxylated by prolylhydroxylases, which tag HIF-1α upon binding of Von Hippel-Lindau (VHL) protein for proteasomal degradation. Hypoxic conditions lead to the inactivation of these enzymes and thus stabilization of HIF-1α, allowing it to accumulate in the nucleus and activate the transcription of its target genes. The pound symbol (#) is used when no line is specified and/or lines are pooled. |
