| Primary Identifier | MGI:7510130 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Fus |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| description | GFP-expressing LB10 mouse embryonic stem cells derived from a C57BL6/N mouse. |
| molecularNote | A proline to leucine substitution at amino acid 527 (p.P517L) was introduced in exon 15. The FRT-flanked neomycin resistance cassette that was inserted 50 bp downstream of the end of the 3â UTR was removed via flp-mediated recombination. This mutation is equivalent to the human P525L allele associated with a rapidly progressive, juvenile-onset form of amyotrophic lateral sclerosis. |
