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Allele : Mmp14<tm1.1Pami> matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1.1, Paolo Mignatti
Primary Identifier  MGI:7511770 Allele Type  Targeted
Attribute String  Not Specified Gene  Mmp14
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  Tyrosine codon 573 (TAC) in exon 10 was changed to aspartic acid (GAC) (p.Y573D) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 9. The neo cassette was removed through subsequent Cre-mediate recombination. The mutation changes the residue in the cytoplasmic tail of the encoded peptide from phosphorylatable to a phosphomimetic.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • Mmp14<Y573D>,
  • Mmp14<Y573D>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

4 Publication categories

Trail: Allele




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