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Allele : Igh<tm4.1Mbu> immunoglobulin heavy chain complex; targeted mutation 4.1, Meinrad Busslinger

Primary Identifier	MGI:7539572	Allele Type	Targeted
Gene	Igh	Transmission	Germline
Strain of Origin	(C57BL/6 x 129P2/OlaHsd)F1	Is Recombinase	false
Is Wild Type	false

molecularNote

The allele was generated by Cre-mediated deletion of 890kb genomic sequence of the lox71/loxP-flanked Igh region in Igh^tm4Mbu. The deletion left the Pgk1 promoter-driven blasticidin resistance gene.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
Igh<Pgk1-delta890>,
Igh<Pgk1-delta890>

earliestPublication:
Hill L, et al. (2023) Enhancers of the PAIR4 regulatory module promote distal V(H) gene recombination at the Igh locus. EMBO J 42(15):e112741

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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