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Allele : Flt3<tm1.1Dgg> FMS-like tyrosine kinase 3; targeted mutation 1.1, D Gilliland
Primary Identifier  MGI:7489690 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Flt3
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  The human W51 mutation which causes the duplication of amino acid 595 to 601 (REYEYDL; AGAGAATATGAATATGATCTC) was inserted in-frame into exon 14, replacing the endogenous single copy (RDYEYDL; AGGGACTATGAATATGACCTT). A loxP site flanked neomycin selection cassette was inserted into intron 15, then was removed via Cre-mediated recombination in the germline.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Flt<ITDdelta>,
  • Flt<ITDdelta>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





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