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Allele : Trem2<em1(cre)Jddl> triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Jiandie D Lin

Primary Identifier	MGI:7490214	Allele Type	Endonuclease-mediated
Attribute String	Recombinase	Gene	Trem2
Strain of Origin	Not Specified	Is Recombinase	true
Is Wild Type	false

description	The mouse line was terminated due to low recombinase activity detected.
molecularNote	Using the CRISPR knockin strategy the Cre recombinase was insetted to endogenous Trem2 via the self-cleavage P2A peptide.

mutations:
Insertion

synonyms:
Trem2-Cre,
Trem2-Cre

earliestPublication:
Zhang P, et al. (2022) Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment. Cell Metab 34(9):1359-1376.e7

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

1 Driven By

2 Publication categories

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