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Allele : Iqcm<em1(IMPC)Tcp> IQ motif containing M; endonuclease-mediated mutation 1, The Centre for Phenogenomics

Primary Identifier  MGI:7510086 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Iqcm
Inheritance Mode  Not Specified Strain of Origin  C57BL/6NCrl
Is Recombinase  false Is Wild Type  false
Project Collection  IMPC
molecularNote  This allele was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with single guide RNAs having spacer sequences of AGCGTGTGCTATGTCGATGC targeting the 5' side and TGACCCATATCCGGGCACAT targeting the 3' side of a critical region (ENSMUSE00000391111). This resulted in a 1128-bp deletion of Chr8 from 76351357 to 76352484 (GRCm39), introducing a frameshift and premature stop codon.
  • mutations:
  • Intragenic deletion
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

3 Publication categories