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Allele : Gt(ROSA)26Sor<em1(CAG-ERBB2*V777L)Bose> gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Ron Bose
Primary Identifier  MGI:7524181 Allele Type  Endonuclease-mediated
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Is Recombinase  false Is Wild Type  false
molecularNote  TALEN technology inserted a CAG promoter, loxP-flanked STOP, and ERBB2 containing a valine to leucine substitution at amino acid 777 into the locus. The p.V777L mutation is a constitutively activated mutation identified in human colorectal cancer patients.
  • mutations:
  • Insertion
  • synonyms:
  • HER2<V777L>,
  • HER2<V777L>
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories





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