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Allele : Col1a1<tm1(tetO-cas9*)Ldow> collagen, type I, alpha 1; targeted mutation 1, Lukas E Dow
Primary Identifier  MGI:7493844 Allele Type  Targeted
Attribute String  Endonuclease, Inducible Gene  Col1a1
Transmission  Germline Strain of Origin  (C57BL/6 x 129S4/SvJae)F1
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting vector was designed to insert an expression optimized iBE reporter construct downstream of the Col1a1 locus. The construct contains a tetO promoter, an optimized BE3RA and rabbit beta globin polyA (RBGpA) sequence. BE3RA contains a rat APOBEC cytidine deaminase at the N-terminus of inactive dCas9 (Cas9-D10A) and a uracil glycosylase inhibitor (UGI) domain at the C-terminus.
  • mutations:
  • Insertion
  • synonyms:
  • TRE-BE3RA,
  • iBE,
  • iBE,
  • TRE-BE3RA
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories





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