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Allele : Taf8<tm1.2Avo> TATA-box binding protein associated factor 8; targeted mutation 1.2, Anne K Voss

Primary Identifier	MGI:7511861	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Taf8
Transmission	Germline	Strain of Origin	C57BL/6
Is Recombinase	false	Is Wild Type	false

molecularNote

A loxP site was inserted upstream of exon 1 and an FRT-flanked neomycin resistance cassette and second loxP site were inserted downstream of exon 7. Exons 1-7 and the neomycin were removed via cre-mediated recombination in the germline.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

earliestPublication:
El-Saafin F, et al. (2022) Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ 29(5):1013-1027

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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