| Primary Identifier | MGI:7513830 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Ank2 |
| Strain of Origin | C57BL/6J x SJL/J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology generated a GAA to GGC change resulting in a glutamic acid to glycine substitution at amino acid 1371 (p.E1371G) in the spectrin-binding domain. Multiple silent coding changes were also introduced to block the Cas9 targets. This corresponds to the human p.E1458G variant associated with arrhythmias and structural remodeling. |
