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Allele : Gt(ROSA)26Sor<tm1(Sirt6)Mpgu> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Mahesh P Gupta
Primary Identifier  MGI:7525638 Allele Type  Targeted
Attribute String  Conditional ready, Epitope tag, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  (C57BL/6NTac x 129S6/SvEvTac)F1
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting vector was designed to insert the Sirt6-FLAG cDNA into the Gt(ROSA)26Sor driven by its promoter and controlled by a STOP cassette. The STOP cassette in the vector consisted of a splice acceptor and the floxed (PGK)/gb2neoPGKpolyA2xSV40pA sequence and was inserted in intron 1 of ROSA26 locus. Mouse Sirt6 cDNA with a C-terminal FLAG tag was cloned immediately downstream of the STOP cassette. The Sirt6-FLAG sequence was followed by a BGHpA bovine growth hormone polyadenylation (BGHpA) sequence.
  • mutations:
  • Insertion
  • synonyms:
  • Tg.Sirt6,
  • Sk.T6Tg,
  • ROSA26-Sirt6-FLAG,
  • ROSA26-Sirt6-FLAG,
  • Tg.Sirt6,
  • Sk.T6Tg
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





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