| Primary Identifier | MGI:7541328 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Slc39a8 |
| Transmission | Germline | Strain of Origin | C57BL/6 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Alanine codon 393 (GCT) in exon 7 was changed to threonine (ACT) (p.A393T) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 8. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation is the equivalent of the human p.A391T mutation (SNP rs13107325) associated with numerous traits, including reduced arterial blood pressure, increased body mass index and hyperlipidemia. |
