| Primary Identifier | MGI:7516790 | Allele Type | Targeted |
| Attribute String | Constitutively active, Humanized sequence | Gene | Fgfr3 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An asparagine to lysine substitution at amino acid 534 (p.N534K) was introduced in exon 12. A loxP-flanked neomycin/STOP cassette that was inserted upstream of exon 11 was removed via flp-mediated recombination. This corresponds to the p.N540K gain-of-function mutation identified in patients with hypochondroplasia. |
