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Allele : Del(16Ifnar2-Ifngr2)1Jmes deletion, Chr 16, Joaquin M Espinosa 1

Primary Identifier	MGI:7543063	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Del(16Ifnar2-Ifngr2)1Jmes
Strain of Origin	C57BL/6NTac	Is Recombinase	false
Is Wild Type	false

molecularNote

A 192 kb genomic segment encoding all four Ifnr genes, Ifnar2, Il10rb, Ifnar1, and Ifngr2, was deleted via CRISRP/Cas9 technology. Whole genome sequencing (WGS) confirmed the heterozygous deletion without other substantial genomic alterations.

mutations:
Intergenic deletion

synonyms:
Ifnr<->,
Ifnr<->

earliestPublication:
Waugh KA, et al. (2023) Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model. Nat Genet 55(6):1034-1047

1 Feature

Genome

0 Expresses

4 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

2 Publication categories

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