| Primary Identifier | MGI:7532647 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(Flt1-cre/ERT2)1Tmak |
| Strain of Origin | C57BL/6NTac | Induced With | tamoxifen |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | A BAC (B6Ng01-247E8) carrying the mouse Flt1 gene was used to generate a transgene by replacing the coding sequence in exon 1 as well as the splice donor site at the junction between exon 1 and intron 1 (50 bp) with a cassette containing the open reading frame for CreERT2 and the Flt1 3' untranslated region. A polyadenylation signal (human growth hormone polyadenylation signal) was inserted 3' of the Flt1 3'UTR sequence. Two independent founder lines were generated, of which one (line 1) showed efficient Cre-mediated recombination and was used for further analyses. |
