|  Help  |  About  |  Contact Us

Allele : Cib2<em1Mll> calcium and integrin binding family member 2; endonuclease-mediated mutation 1, Ulrich Muller

Primary Identifier  MGI:7529458 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Cib2
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  Glutamic acid codon 64 (GAG) in exon 3 was changed to aspartic acid (GAC) (p.E64D) using crRNA, tracrRNA and an ssODN template with CRISPR/Cas9 technology. The mutation affects mechanoelectrical transduction (MET) by cochlear hair cells and causes deafness.
  • mutations:
  • Single point mutation
  • synonyms:
  • Cib2<E64D>,
  • Cib2-E64D,
  • Cib2<E64D>,
  • Cib2-E64D
Quick Links:
 
Quick Links:
 

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories