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Allele : Cib2<em2Mll> calcium and integrin binding family member 2; endonuclease-mediated mutation 2, Ulrich Muller

Primary Identifier  MGI:7529459 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Cib2
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  Isoleucine codon 123 (ATC) in exon 5 was changed to threonine (ACC) (p.I123T) using crRNA, tracrRNA and an ssODN template with CRISPR/Cas9 technology. The mutation affects mechanoelectrical transduction (MET) by cochlear hair cells and causes deafness.
  • mutations:
  • Single point mutation
  • synonyms:
  • Cib2<I123T>,
  • Cib2-I123T,
  • Cib2<I123T>,
  • Cib2-I123T
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories