| Primary Identifier | MGI:7517250 | Allele Type | Targeted |
| Gene | Ahsp | Transmission | Germline |
| Strain of Origin | 129S/SvEv | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Proline codon 30 (CCT) in exon 3 was changed to tryptophan (TGG) (p.P30W) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 2. The neo cassette was removed through subsequent Cre-mediated recombination. The affected residue is located in loop 1, between helix 1 and 2, of the encoded peptide and is thought to be involved in oxygenated alpha-globin binding. |
