Primary Identifier | MGI:7545038 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Elac2 |
Strain of Origin | C57BL/6N | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Alanine codon 537 (GCT) in exon 17 was changed to threonine (ACT) (p.A537T) using an sgRNA and an ssODN template with CRISPR/Cas9. The mutation is the equivalent of the human p.A541T mutation associated with prostate cancer predisposition. |