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Allele : Tg(Prnp-Ldlr)EHol transgene insertion E, David M Holtzman

Primary Identifier	MGI:7548807	Allele Type	Transgenic
Attribute String	Inserted expressed sequence	Gene	Tg(Prnp-Ldlr)EHol
Strain of Origin	C57BL/6 x CBA	Is Recombinase	false
Is Wild Type	false

molecularNote

A mouse prnp promoter drives expression of a mouse Ldlr cDNA. Two lines were generated, a high-expressing B line and low-expressing E line.

mutations:
Insertion

earliestPublication:
Kim J, et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64(5):632-44

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

1 Driven By

3 Publication categories

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