| Primary Identifier | MGI:7548550 | Allele Type | Targeted |
| Gene | Esr1 | Transmission | Germline |
| Strain of Origin | C57BL/6NCrl | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Arginine 264 (CGA) in exon 5 was changed to alanine (GCA) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 5. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation abrogates the rapid dilation of mesenteric arteries and the acceleration of endothelial repair of carotid actions of the encoded peptide without affecting other functions. |
