| Primary Identifier | MGI:7550418 | Allele Type | Targeted |
| Gene | Kcnq2 | Transmission | Germline |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Serine codon 559 (AGT) in exon 13 was changed to alanine (GCC) (p.S559A) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 13. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation prevents phosphorylation of the affected residue in the encoded peptide, which lowers its affinity for phosphatidylinositol 4,5âbisphosphate (PIP2). |
