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Allele : Otof<em2Bros> otoferlin; endonuclease-mediated mutation 2, Nils Brose
Primary Identifier  MGI:7571452 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Otof
Inheritance Mode  Not Specified Strain of Origin  C57BL/6NCrl
Is Recombinase  false Is Wild Type  false
molecularNote  This mouse line was generated by site-directed CRISPR-Cas9 mutagenesis in C57BL/6NCrl mice causing D1543A/D1545A/D1550A mutation (Corresponds to D1563A/D1565A/D1570A mutation in the isoform e peptide coded for by the human ortholog). Additional silent mutations were introduced. The mutated exon38 now reads:(5')gtcctttgacattgaggcctccttccccatggagtccatgttgacagtggccgtgtacgCctgggCtctggtgggcacAgCtgaTctcatcggagaaaccaagattgacctggaaaaccgcttctacagcaagcatcgcgccacctgcggcatcgcacagacctattccat(3')
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Otof<D1563/1565/1570A>,
  • Otof<TDA>,
  • Otof<TDA>,
  • Otof<D1563/1565/1570A>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories





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