Primary Identifier | MGI:7571554 | Allele Type | Endonuclease-mediated |
Gene | Malt1 | Strain of Origin | (C57BL/6N x 129-Malt1<em1Krad>)F1 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | CRISPR/Cas9 technology generated the paracaspase mutation, a TGT to GCG change resulting in a cysteine to alanine change at amino acid 472 (p.C472A) in exon 11, in zygotes carrying the Malt1em1Krad allele. These mice thus carry the p.C472A mutation as well as p.E324A, p.E814A, and p.E803A. |