| Primary Identifier | MGI:7607160 | Allele Type | Targeted |
| Attribute String | Conditional ready | Gene | Trp53 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP site flanked STOP cassette was inserted into intron 1 and leucine codon 25 (TTA) in exon 2 was changed to glutamine (CAA), tryptophan codon 26 (TGG) in exon 2 to serine (TCG) and arginine codon 172 (CGC) in exon 5 to histidine (CAC) (p.L25Q, p.W26S, p.R172H). The mutations, in the transactivation domain (TAD) of the encoded peptide, renders the peptide transactivation-deficient. |
