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Allele : Trp53<tm1Sdeb> transformation related protein 53; targeted mutation 1, Sumitra Deb
Primary Identifier  MGI:7607160 Allele Type  Targeted
Attribute String  Conditional ready Gene  Trp53
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A loxP site flanked STOP cassette was inserted into intron 1 and leucine codon 25 (TTA) in exon 2 was changed to glutamine (CAA), tryptophan codon 26 (TGG) in exon 2 to serine (TCG) and arginine codon 172 (CGC) in exon 5 to histidine (CAC) (p.L25Q, p.W26S, p.R172H). The mutations, in the transactivation domain (TAD) of the encoded peptide, renders the peptide transactivation-deficient.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • p53 LSL-L25Q/W26S/R172H,
  • p53 LSL-L25Q/W26S/R172H
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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