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Allele : B2m<em2(HLA-A11.1,B2M,H2-D1)Gpt> beta-2 microglobulin; endonuclease-mediated mutation 2, GemPharmatech

Primary Identifier	MGI:7576249	Allele Type	Endonuclease-mediated
Attribute String	Humanized sequence, Inserted expressed sequence, Null/knockout	Gene	B2m
Inheritance Mode	Not Specified	Strain of Origin	BALB/cJGpt
Is Recombinase	false	Is Wild Type	false

molecularNote

CRISPR-targeting replaced the mouse gene with a portion of the highly frequent HLA-A*11:01 gene sequence, the human B2M coding sequence, and a portion of the mouse H2-D1 coding sequence.

mutations:
Intragenic deletion,
Insertion

synonyms:
b2m<em1Cin(hHLA-A11.1,hB2m,H2-D1)>,
b2m<em1Cin(hHLA-A11.1,hB2m,H2-D1)>

earliestPublication:
GemPharmatech (2020) GemPharmatech Website.

1 Feature

Genome

2 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

2 Publication categories

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