| Primary Identifier | MGI:7576954 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Crx |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Lysine codon 88 (AAG) in exon 4 was changed to asparagine (AAC) (p.K88N) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation, in the homeodomain (HD) of the encoded peptide, is the equivalent of same human mutation associated with dominant Leber congenital amaurosis 7 (LCA7). |
