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Allele : Ripk4<tm1.1Vmd> receptor-interacting serine-threonine kinase 4; targeted mutation 1.1, Vishva M Dixit

Primary Identifier	MGI:7580819	Allele Type	Targeted
Attribute String	Not Specified	Gene	Ripk4
Transmission	Germline	Strain of Origin	C57BL/6
Is Recombinase	false	Is Wild Type	false

molecularNote

Aspartic acid codon 161 (GAC) in exon 3 was changed to asparagine (AAC) (p.D161N). Intron 2 contains a lox511 site and intron 3 a loxP site. The mutation renders the encoded peptide catalytically inactive.

mutations:
Insertion,
Single point mutation

cellLines:
Not Specified

synonyms:
Ripk4<D161N>,
Ripk4<D161N>

earliestPublication:
Oberbeck N, et al. (2019) The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function. Nature 574(7777):249-253

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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