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Allele : Itgam<tm1.1Rivp> integrin alpha M; targeted mutation 1.1, Roberto I Vazquez-Padron
Primary Identifier  MGI:7638771 Allele Type  Targeted
Attribute String  Constitutively active Gene  Itgam
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  Isoleucine codon 332 (ATC) in exon 9 was changed to glycine (GGC) (p.I332G) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 8. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation renders the encoded peptide constitutively active.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • CD11b<I332G>,
  • CD11b<I332G>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

3 Publication categories

Trail: Allele




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