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Allele : Gt(ROSA)26Sor<em1(CAG-TBL1XR1/TP63,-EGFP)Mybr> gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Myles Brown
Primary Identifier  MGI:7579420 Allele Type  Endonuclease-mediated
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter Gene  Gt(ROSA)26Sor
Strain of Origin  (C57BL/6 x DBA/1)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 technology inserted a CAG promoter, a loxP-flanked neomycin/Stop cassette, human TBL1XR1/TP63 fusion cDNA, IRES and EGFP. The TBL1XR1::TP63 rearrangement, in which the breakpoint is in the WD40 repeat domain of TBL1XR1 and right after the transactivation domain of the TP63, is the most common TP63 fusion seen in lymphomas.
  • mutations:
  • Insertion
  • synonyms:
  • TgTT,
  • TgTT
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1 Feature

Genome

2 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Carried By

1 Driven By

2 Publication categories





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