| Primary Identifier | MGI:7581997 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Lmna |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Tryptophan codon 520 (TGG) in exon 9 was changed to arginine (CGG) (p.W520R) using sgRNAs and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the same human mutation associated with Emery-Dreifuss muscular dystrophy (EDMD2). |
