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Allele : E2f3<tm1.1Weidu> E2F transcription factor 3; targeted mutation 1.1, Wei Du
Primary Identifier  MGI:7593769 Allele Type  Targeted
Gene  E2f3 Transmission  Germline
Strain of Origin  C57BL/6 Is Recombinase  false
Is Wild Type  false
molecularNote  Leucine codon 430 (CTG) in exon 7 was changed to glutamine (CAG) (p.L430Q) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 6. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation, in the highly conserved Rb-binding domain of the encoded peptide, blocks retinoblastoma-family-protein-binding.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • E2F3<LQ>,
  • E2F3<LQ>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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