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Allele : Tbc1d20<em1Djsi> TBC1 domain family, member 20; endonuclease-mediated mutation 1, Duska J Sidjanin

Primary Identifier	MGI:7593975	Allele Type	Endonuclease-mediated
Gene	Tbc1d20	Strain of Origin	(C57BL/6 x DBA/2)F1
Is Recombinase	false	Is Wild Type	false

molecularNote

Zinc finger nuclease (ZFN)-mediated genomic editing resulted in a 9 bp deletion (c.418_426del) in exon 4 which produces a mutant protein with an in-frame 3 amino acid deletion (p.H140_Y143del) within a highly conserved TBC domain.

mutations:
Intragenic deletion

synonyms:
Tbc1d20<ZFN>,
Tbc1d20<ZFN>

earliestPublication:
Park AK, et al. (2014) Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. BMC Genet 15:135

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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