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Allele : Ms4a7<em1.1Jddl> membrane-spanning 4-domains, subfamily A, member 7; endonuclease-mediated mutation 1, Jiandie D Lin

Primary Identifier	MGI:7640119	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Ms4a7
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

molecularNote

Exon 2, which contains the start of the coding region, was flanked by loxP sites via CRISPR/Cas9 technology. Cre-mediated recombination deleted exon 2. Western blot analysis confirmed the absence of protein in liver.

mutations:
Insertion,
Intragenic deletion

earliestPublication:
Zhou L, et al. (2024) Hepatic danger signaling triggers TREM2(+) macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation. Sci Transl Med 16(738):eadk1866

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

3 Publication categories

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