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Allele : Irf6<tm3.1Vmd> interferon regulatory factor 6; targeted mutation 3.1, Vishva M Dixit
Primary Identifier  MGI:7595818 Allele Type  Targeted
Attribute String  Constitutively active Gene  Irf6
Transmission  Germline Strain of Origin  C57BL/6NTac
Is Recombinase  false Is Wild Type  false
molecularNote  Serine codons 413 (TCC) and 424 (TCC) in exon 8 were changed to glutamic acid (GAA) (p.S413E, p.S424E) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 7. The neo cassette was removed through subsequent Flp-mediated recombination. The mutations change phosphorylatable residues in the encoded peptide into phosphomimetics.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Irf6<S413E,S424E>,
  • Irf6<S413E,S424E>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories





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